Arteriosclerosis - Causes determinants and predisposing

Cholesterol and Atherosclerosis

The why, how and when it appears atherosclerosis is one of the many discussions of medicine.

We mention below some of the theories on why arteriosclerosis.

Theory nutrition impaired arterial walls

It is believed that such mechanical factors, toxic or functional part in poor nutrition of the arterial walls. This theory is supported by pathological findings of lesions of a degenerative nature.

Theory cholesterol turnover 

In animal studies have shown that cholesterol causes the appearance of lesions of the arterial walls similar to those of atherosclerosis in humans. With the passage of time increases the rate of cholesterol in the blood and is associated with arterial injury. A test that can confirm this theory is the fact that in areas or countries where food is relatively low in cholesterol accident mortality of atherosclerosis is lower than in many Western countries.

Theory mecánicofuncionales

This theory assumes that atherosclerosis is caused by the relaxation of arterial walls caused by blood contained in the vascular bed and the subsequent reaction of the walls, which is manifested in the formation of fibrous connective tissue. According to the observation of other authors of vascular lesions, we see that are the arteries that branch off collateral branches or those that tend to suffer more damage. Some believe that the pressure of the blood in the arteries heart contractions on arterial injury occurs.

Theory toxic

Other researchers believe that atherosclerosis is caused by the toxicity that accumulates in the arterial walls. This toxicity may be due to external or internal level, from snuff, alcohol, free radicals, misfeeds, etc., Etc. This theory is related to the first.
There have been more theories about the cause of arteriosclerosis in the past, but surely there is no single factor that leads to this disease, but a combination of several factors in turn.

Predisposing causes of arteriosclerosis

But besides these factors are predisposing factors that affect the incidence of the disease. These typically include:

Age. Although not unique arteriosclerosis adulthood, the vast majority of cases in old age, and many associated with aging phenomena are due directly or indirectly to arteriosclerosis.

Obesity. For daily clinical experience and statistics, atherosclerosis is a disease linked to obesity rather than thin people. But not only matter of overeating associated with obesity, but by the difficulty in organic metabolism and hypertension that often accompanies obesity.

The constitutional predisposition. It appears that under certain people have inheritance hypersensitivity vasomotor centers of the brain bulb, secretory abnormalities and some endocrine glands, especially a congenital weakness arterial walls.

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