Acute pyelonephritis. Definition

Medical Definition: Acute pyelonephritis

Condition characterized by a nonspecific bacterial infection of the renal and upper urinary tract (pelvis and calyces). There is a polymorphonuclear inflammatory cell infiltrate, and sometimes, microabscesses in the renal interstitium. The infection may have a hematogenous origin, usually ascending, with predisposing factors such as uropathies (type stones, obstruction, vesicoureteral reflux), predisposing diseases (diabetes mellitus, analgesic nephropathy, etc.).. Associated with fever, chills and flank or abdominal pain, nausea, vomiting, myalgia, and dysuria, urinary frequency. Can cause metastatic infections (skeleton, endocardium, ocular, central nervous system) and generalized sepsis. The germs can reach the kidney by blood up from the bladder (the majority), or via the lymphatic system from the gut. They are more common in women and facilitating factors are pregnancy or the presence of urinary obstruction, vesicoureteral reflux, neurogenic bladder and urological maneuvers (catheterization, lithotripsy, etc.).. The identification of the germ is carried out with cultures of urine and blood. Treated with antibiotics, sometimes for long periods.

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