Anaerobic bacteria in the treatment of cancer. Definition

Medical Definition: Anaerobic bacteria in the treatment of cancer

New anti-tumor therapy by combining the action of anaerobic bacteria killer with cytostatic agents. Cytostatic drugs in current use are limited in part triggered by the inability of these drugs to destroy tumor cells within poorly vascularized compartments Therefore began investigating mechanisms by which these areas could be destroyed from lack of oxygen peripheral tumor . The Howard Hughes Medical Institute, The Johns Hopkins School of Medicine, and The Johns Hopkins Oncology Center, pointed to the anaerobic bacteria for their ability to grow expansively within poorly vascularized tumor compartment, within the transplanted tumors in mice. Among the 26 strains of bacteria tested, only one (Clostridium novyi) appeared to be particularly promising antitumor treatment. Dang LH, Bettegowda C, Huso DL, Kinzler KW, Vogelstein B. created a strain of C. Novyi free of lethal toxin, which they called C.novyi-NT and showed that intravenously inoculated in mice, the spores germinated within the avascular regions of tumors and destroying the viable tumor cells. When spores were administered C.novyi-NT with conventional qumioterápicas drugs were developed within 24 hours, extensive intratumoral foci of hemorrhagic necrosis, resulting in a significant and prolonged antitumor effect. This strategy, called combination bacteriolytic therapy (COBALT), is a new dimension in anti-tumor therapy is concerned.

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