Burkitt Lymphoma. Definition

Medical Definition: Burkitt Lymphoma

An aggressive (fast growing) non-Hodgkin lymphoma of B cells that occurs most often in children and young adults. The disease can affect the jaw, central nervous system, gut, kidneys, ovaries or other organs. There are three main types of Burkitt lymphoma: sporadic, endemic and associated with immunodeficiency. Sporadic Burkitt lymphoma occurs throughout the world, endemic Burkitt lymphoma occurs in Africa and the Burkitt lymphoma associated with immunodeficiency is most often seen in AIDS patients. It is a solid tumor of B lymphocytes characterized by small noncleaved uniform in appearance. It is classified as a high-grade lymphoma, and one of the fastest growth rate (it can even double every 24 hours). This type of lymphoma was first described in 1958 by Denis Parsons Burkitt as a malignant neoplasm of the jaw, located in Central Africa. Later, in 1965, described O'Connor's lymphoma in North America with histopathologic features identical to those of the African condition.

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