Cushing's Disease. Definition

Medical Definition: Cushing's Disease

A condition in which too much cortisol (a hormone made in the outer layer of the adrenal gland) in the body. Cushing's disease, when an adenoma (benign tumor) in the pituitary gland produces too much adrenocorticotropic hormone (ACTH) that causes the adrenal gland to make too much cortisol. Symptoms include a round face, thin arms and legs, severe fatigue and muscle weakness, high blood pressure and high concentration of sugar in the blood, purple or pink stretch marks on the skin, and weight gain, especially in the abdomen.

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