HER2/neu gene. Definition

Medical Definition: HER2/neu gene

This oncoprotein is present in very small amounts in the outer surface of normal breast cells. About 25% to 30% of breast cancers have this protein in excess. The HER stimulates cell growth, and breast cancer tumors that produce large amounts of this protein tend to be more aggressive. A monoclonal antibody that binds to the HER2 protein slows the growth of breast cancer cells and can also stimulate the immune system to attack cancer more effectively. Other cancers are also abundant protein HER2/neu. At present studies are of monoclonal antibody therapy for these cancers.

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