HLA identical transplant. Definition

Medical Definition: HLA identical transplant

Transplant carried out with a living related donor (or body), which shares with the receiver the two haplotypes or six HLA antigens. Evidence that the HLA system is the most histocompatibility complex in humans comes from the experiments of skin grafts, living related donor transplants and bone marrow transplants. Within a family, the degree of histocompatibility between siblings might share two haplotypes (HLA identical) haplotypes (haplo-identical) or none. Parents and children share a haplotype. In the transplantation of a living related donor, the best results correspond to those between HLA-identical siblings, followed by those who share a haplotype, and finally those who do not share any haplotype. These results decrease from a year graft survival of 95-98% in the first case, to 90-95% for the second and finally to 80-90% for the latter.

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