Hemolytic uremic syndrome. Definition

Medical Definition: Hemolytic uremic syndrome

Thrombotic microangiopathy manifested by hemolytic anemia, thrombocytopenia with consumption coagulopathy and acute renal failure, often oliguric. An injury of vascular endothelium with a local activation of coagulation and thrombosis formation in small vessels. The causes are multiple: infectious (Escherichia coli, Salmonella, etc.), Toxic or drug (cyclosporine A, anti-inflammatory drugs), in the course of collagen disease (lupus erythematosus, scleroderma, etc..), Pregnancy or may be idiopathic. Presents with microangiopathic hemolytic anemia, thrombocytopenia, abnormal coagulation factors (fibrinogen, factors dependent on vitamin K, factors V and VII, etc.), Hematuria, proteinuria and elevated serum creatinine and urea. Are typical findings of renal biopsy (lesion with thickening and arteriolar wall necrosis, capillary thrombosis and fibrinogen or fibrin deposits).

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