Koch's postulates. Definition

Medical Definition: Koch's postulates

Series of conditions that, according to the German microbiologist Robert Koch (1843-1910), must be satisfied that a body may be regarded as the causal agent of a disease: the organism must be found in all individuals who have the disease, the agency must be isolated in pure culture, the pure culture must cause the disease when inoculated with an experimental animal, the causative organism must be isolated again from the sick animal, and again identified in pure culture. There are numerous cases of human pathogens (eg., Non-culturable on artificial media such as Treponema pallidum bacteria or viruses) that do not fulfill Koch's postulates, however, their direct involvement, to cause a particular disease, is well established.

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