Acute rejection. Definition

Medical Definition: acute rejection

Cell-type immune response and humoral receiver tries to destroy the graft. Is the main cause of graft loss in the first year after transplantation. It can be hyperacute (antibody-mediated cytotoxic preformed occurs immediately after declamping blood and irreversible), speed (similar to HAR, but occurs between the second and sixth day of transplantation) and acute (the most common and occurs mainly between five to ninety days after renal transplantation). The classic symptoms of acute rejection include fever, discomfort in the area of ??the graft, oliguria, a feeling of malaise, hypertension and increased graft size. Is always associated with increased serum creatinine. Since the introduction of cyclosporine as an immunosuppressant, the above symptoms can be very mild. Also occurs in other organ transplants (heart, liver, pancreas, etc.).. Among the diagnostic methods of rejection three stand out: the ultrasound scan and biopsy of the graft.

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