Antiglobulin test. Definition

Medical Definition: antiglobulin test

One that uses an antibody as a reagent (antiglobulin) can bind to molecules of IgG or complement C3d fraction attached to the membrane of erythrocytes and cause agglutination of these. Also called direct Coombs test, used to diagnose autoimmune hemolytic anemia, drug-induced hemolytic anemia, hemolytic disease of the newborn, transfusion reactions transfused red cells of the immune nature. Indirect antiglobulin test and indirect Coombs shows awareness of the red blood cells produced in vitro has several purposes: pretransfusion crossmatch, investigation of anti-erythrocyte antibodies in serum, determination of erythrocyte phenotype by specific sera.

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