Complement system. Definition

Medical Definition: complement system

Serum multiprotein complex (more than 20 proteins) involved in controlling inflammation, activation of phagocytosis and lytic attack on cell membranes. It can be activated via the classical (components C1, C4, C2 and C3, mediated by immune complexes containing IgG or IgM or bacteria, viruses, lipopolysaccharide, etc..) Or alternative pathway (see alternative pathway of complement). Both pathways function as cascaded amplifier systems, with the C3-convertase enzyme that activates the C3 (a major component of the complement system, generating peptides with multiple effects, opsonization, chemotaxis, vasodilation and increased permeability, cell lysis, etc. .).

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