Deficit syndrome of MHC class II. Definition

Medical Definition: deficit syndrome of MHC class II

Character combined immunodeficiency autosomal recessive congenital, characterized by a deficiency in the expression of molecules of the major histocompatibility complex class II in B lymphocytes, macrophages and dendritic cells. Appears mainly in children in northern Africa, and is characterized by the presence of normal numbers of B and T lymphocytes, with agammaglobulinemia and decreased cellular immunity, which determines the presence of recurrent infections, often associated with malabsorption and diarrhea. Also called bare lymphocyte syndrome.

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