Kallikrein-kinin system. Definition

Medical Definition: kallikrein-kinin system

Vasodilator, vasopressor important component of cardiovascular control. In mammals, the main kinins are bradykinin and lysyl-bradykinin (kallidin). Are released from kininogen substrates known as by enzymes called cininogenasas, of which the main are plasma kallikrein and tissue (glandular), which have different functions. There are two main kininogen: the high molecular weight kininogen (acted upon plasma kallikrein) and low molecular weight, both synthesized in the liver. Kinins are destroyed by enzymes called kininases, which are located in the lungs and other tissues (angiotensin converting enzyme or kininase II, endopeptidases, aminopeptidases and carboxypeptidases). Kinins act on receptors ² ² -1 and -2 (vasodilation) and have a natriuretic and diuretic effect. There is a renal and other vascular kallikrein-kinin.

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