Vitamin B6. Pyridoxine. You have side effects?

Investigations of the side effects that can produce vitamin B6 or pyridoxine in high doses. Range safety of this vitamin.

The review of the literature which implements a Haskell revealed no incidence of adverse effects in patients treated with a daily oral dose of 20-100 mg pyridoxine (ie up to 50 times the RDA) for up to 3-4 years .

The panel of the Food and Drug Administration also concluded that in man, side effects were not found with a daily administration of 50-200 mg of pyridoxine hydrochloride on periods of several months.

However, recent reports describe several patients who experienced a sensory neuropathy after ingestion of excessive doses of pyridoxine (up to 6 grams a day) for long periods.

An intake of 500 mg of pyridoxine daily can cause a neuropathy after a prolonged ingestion for several years and even higher doses, after a shorter period. The neuropathy is usually reversible with the suppression of pyridoxine. "The margin of 200-500 mg daily dose has not been studied systematically, but the threshold seems to be above this range and depends largely on the duration of treatment."

It has been argued that high doses of pyridoxine may lead to liver damage, interference with normal functions of riboflavin and a situation of dependency. With the possible exception of dependence, these claims have not been substantiated with scientific data. The states of dependency, consisting of poorly defined symptoms, among which include nervousness and tremors have been induced in three adult subjects eventually have after pyridoxine hydrochloride supplementation, after a few weeks to a level of 200 mg daily (100 times the RDA for adults), but the reaction was very transient.

Based on current evidence, it is generally accepted that the security level for a prolonged administration is between 50 and 100 times the RDA.

Related topics:
Vitamins. Have side effects doses?
Vitamin B4, B5, B6, B7, B8

*Automatic Translation