Vitamin E: There any side effects at high doses?

Investigations of possible side effects that can produce vitamin E in high doses. Range safety of Vitamin E

A review of 216 trials with high doses of vitamin E on 10,000 patients shows that a daily dose of 3,000 IU for up to 11 years and 55,000 iu for a few months had no negative effect on a variety of clinical and biochemical parameters.

The high-dose therapy was well tolerated, with only 0.8% of patients with minor side effects indole. Occasional side effects in patients under oral ingestion, reviewed by Briggs in 1978, not a reason to create concerns and always reversible with discontinuation of therapy.

Other studies, 100-800 u.i. of vitamin E daily for an average of 3 years, with 1,600 iu for 6 months, with 3,200 u.i. for 9 weeks or 200-3.000 u.i. for up to 11 years, only rarely showed slight gastrointestinal discomfort, no adverse effects on court to assess the functions using a wide range of specific tests.

By contrast, in cases of premature infants, high doses of vitamin E, particularly intravenously, have been associated with unexplained deaths and the increasing frequency of necrotizing enterocolitis, sepsis, and liver and kidney damage. Its cause is unclear, but may have been associated with the pharmaceutical preparation method before the administration of high levels of vitamin.

Vitamin E may exacerbate the anticoagulant effects of vitamin K antagonists such as warfarin and is therefore contraindicated when you are applying anticoagulant therapy by mouth.

With the exception of those treated with anticoagulants, it is suggested that a dose much more than 100 times the RDA can be safely administered.

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